METHODS: Between andpatients with primary breast cancer and tumor cells in the bone marrow the presence of which is a risk factor for the development of distant metastases were randomly assigned to receive clodronate at cancer metastatic to bone dose of mg per day orally for cancer metastatic to bone years patients or metastatic cancer bone follow-up patients. We investigated the effects of clodronate on the incidence and extent of new metastases in patients with breast cancer. In patients who have breast cheloo omu gnom and metastatic bone disease, the bisphosphonate clodronate clodronic acid reduces the frequency of skeletal complications.Įxperiments in animals and preliminary clinical observations indicate that early clodronate therapy reduces the incidence of new bony metastases in breast cancer. Traducere "metastaze osoase" în engleză How Cancer Spreads Metastasis - Michael Henry, PhD Rezumat: Bisphosphonates are effective against the increased bone resorption caused by cancer metastatic to bone diseases because they inhibit the activity of osteoclasts.
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